1.[ RAPA ] [ Rapamune ] [ Sirolimus ] [ AY-22989 ] [ NSC-226080 ]

Medical applications :Rapamycin ( Sirolimus ) is an immunosuppressant and is used to prevent rejection of kidney and liver transplants. It is also used sometimes in cases of psoriasis, dermatitis.

Research Rapplications:Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Rapamycin inhibits T-lymphocyte activation / proliferation occuring in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressing agents. Sirolimus also inhibits antibody production.

Cyclosporine A is an immunosuppressant and is used to prevent rejection of kidney and liver transplants. Also it is a effective component for the dry eyes. Anymore, Cyclosporine A (CsA) has been reported as an effective therapy for idiopathic membranous nephropathy (IMN),［ 3-5 ］which is similar with MLN in renal histology.